The Pats and the Bucs both lead their division and meet in one of the more compelling games of Week 10.
The Colts have jumped to the front of the AFC South with the Jags and Texans now battling it out for a wild card spot unless things turn around fast.
Baltimore are getting some troops back led by star QB Lamar Jackson and look a good bet to best Minnesota who seem to be in a major letdown spot.
The Bills and Dolphins are operating at different ends of the spectrum this year but Miami are one of the better bets to cover in Week 10.
Both Cleveland and New York are in desperate need of a win but with two weeks to prepare Cleveland look to be in a much better spot.
Carolina are above .500 despite being underdogs in every game this year and are set to start favourites for the first time in 2025 when hosting the Saints.
The Giants look set to ride rookie QB Jaxson Dart to an upset win over the Bears in Chicago with the Bears in a bad spot.
It's a battle between first and last in the AFC West when Las Vegas travel to Denver on Thursday Night Football.
The Dallas Cowboys and their high scoring ways travel to Arizona to play the Cardinals on Monday Night Football.
Washington welcomes back star quarterback Jayden Daniels into the lineup when they host Seattle on Sunday Night Football.