The Rams were shocked by the Panthers last week and will be looking to get back on track against their NFC West rivals.
The Bears are currently the number one seed in the NFC, but nevertheless head to Lambeau Field as big outsiders in what shapes as a pivotal game.
These teams will be hoping to improve on the Week 10 match won 10-7 by the Broncos, one of the worst games of professional sport ever played.
Indianapolis and Jacksonville are tied at 8-4 so this game will be critical in determining who wins the AFC South.
Neither the Dolphins or the Jets are heading to the playoffs but there is always something compelling when these two AFC East teams meet.
The return of Joe Burrow remarkably has the 4-8 Bengals in with a chance of sneaking the AFC North and that bodes poorly for the inconsistent Bills.
The AFC North is one of the most hard-fought divisions in the NFL and with the division crown on the line this shapes as another clash that will be tightly contested.
Seattle have been outstanding on the road under Mike MacDonald and should have few problems with an Atlanta team on the verge of firing coach Raheem Morris.
Minnesota have endured some utterly horrific quarterback play so it is stunning that they have opened favourites against a Washington team that nearly rolled Denver.