North 'host' Fremantle at Optus Stadium on Saturday night in the second week of their WA jaunt.
The undermanned Bombers face a tough test in Geelong at the MCG on Saturday afternoon.
The Lions will be looking to bounce back from a wasteful loss to Adelaide when they host GWS at the Gabba on Saturday.
Adelaide head to Launceston on Friday night to take on the Hawks in a blockbuster match-up of two top four aspirants.
The Western Bulldogs are in need of a win to bounce back into the top eight when they face St Kilda on Thursday night.
The traditional King's Birthday match sees ladder-leading Collingwood square off with Melbourne.
It's the Blues and Bombers on Sunday afternoon at the MCG, a meeting of two great clubs who have been anything but that in recent years.
The Spoon-bowl hits south-west WA on Sunday afternoon as North 'host' West Coast in Bunbury's first official AFL match.
The Giants face the Power in Canberra on Saturday night in a meeting of two highly-inconsistent teams.
It's fourth against fifth on Saturday when the Suns head down the highway to take on the Cats at GMHBA Stadium.
The Tigers get an opportunity for their fourth win of the season on Saturday afternoon against a struggling Sydney.
Friday night footy sees Adelaide host Brisbane in what should be a fantastic match-up.
It's sixth vs ninth at Marvel Stadium to kick off AFL Round 13 with the Bulldogs facing the Hawks.
Round 12 concludes with last-placed West Coast hosting fifth-placed Geelong at Optus Stadium. This could get ugly.
The resurgent Dees face the battling Saints in Alice Springs to kick off Sunday footy.
Sydney are in desperate need of a win to keep their flailing season alive when they face Adelaide at the SCG on Saturday night.
The Giants will be hoping for a percentage booster on Saturday when they host Richmond at Engie Stadium.
Freo are in search of a third straight win when they head to the Gold Coast on Saturday to face the Suns.
A blockbuster top eight match-up awaits at the MCG on Friday night with Collingwood facing Hawthorn.
A beaten up Bombers head to the Gabba on Thursday night to take on the Brisbane Lions.