Round 4 comes to a close out west with Fremantle hosting the Western Bulldogs at Optus Stadium.
The Saints head to Adelaide to face the Power coming off two straight wins, while Ken Hinkley's team will be looking to rebound from a poor loss against Essendon.
The Giants host the Eagles on Sunday afternoon in one of the most one-sided betting markets in football history.
The Roos host the Swans on Saturday night at Marvel Stadium with both sides looking to go 2-2 on the season.
The Lions return to the MCG for the first time since their Grand Final demolition of Sydney. Expect a similar result against Richmond.
The Suns host the Crows on the Gold Coast to kick off Saturday footy in a most unlikely match of the round.
The Dees' miserable start to 2025 looks set to to continue when they head down the highway to meet Geelong on Friday night.
AFL Round 4 kicks off with a high-stakes match-up between the AFL's oldest rivals, Carlton and Collingwood.