San Francisco have won their first two by a combined 42 points and host an Arizona side that managed 151 yards against Seattle.
Best Bet
Brock Purdy is playing as well as any quarterback in football. He has completed 45 of 56 passes for 492 yards and five touchdowns, without being sacked. Against Miami he went 20 of 22 for 287 and San Francisco scored touchdowns on their first five possessions.
The receiving group is thin, with Ricky Pearsall, Christian Kirk and De’Zhaun Stribling all missing and Mike Evans questionable, but George Kittle caught four for 80 and a score last week and Purdy has succeeded with anonymous pass catchers before.
Arizona were exposed by Seattle. Jacoby Brissett threw for 95 yards on 28 attempts, the Cardinals managed 3.2 yards a play and held the ball for 23 minutes 27. Their best young corner, Will Johnson, is now expected to miss the season.
Arizona are 2-8 against the number in their last ten while San Francisco are 7-3.
Back the 49ers.
Same Game Multi
San Francisco have won by a combined 42 points and Arizona could not move the ball last week.
Purdy is averaging 246 yards a game and has barely missed a throw.
McCaffrey gets carries once San Francisco are in front, as they should be early.
Value Bet
McBride’s line is 68.5 and he set the single season record for catches by a tight end last year. He went for nine and 95 in the opener and caught eight more in the loss to Seattle. If San Francisco get out in front as expected, Arizona will be throwing for the second half and McBride is the only receiver they trust.
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