Unbeaten San Francisco host a Denver side that has posted back to back wins off a disappointing Week 1 performance.
Best Bet
The Broncos are a great bet here with the points.
Kyle Shanahan is 2-13 against the number in his last 15 coming off a home win, and the 49ers are 8-18 ATS at home since Week 8 of 2023, including 7-16 as home favourites.
Brock Purdy is 11-13 ATS in his last 23 against teams with lesser records, and San Francisco failed to cover as 7.5-point favourites against Arizona last week.
Denver are 6-1 ATS in their last seven as underdogs, and Sean Payton is 61-42-3 ATS as a dog in his career.
The 49ers are also without Nick Bosa, Mykel Williams and James Thompson Jr.
Take the Broncos and the points.
Same Game Multi
Denver have gone under in two of their three games this season.
Kittle has 80 or more receiving yards in each of his last two games.
Value Bet
Waddle leads Denver with 150 receiving yards on 20 targets and gets a 49ers defence missing three defensive linemen, giving more time for explosive plays to unfold.
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