While Jannik Sinner should cruise through to another Grand Slam Final, the same cannot be said for Carlos Alcaraz when he faces Novak Djokovic.
Two huge women's Semi Finals featuring two Americans in front of their home crowd, and two of the biggest names of international tennis.
Alex De Minaur is on the verge of his first Semi Final at a major, but the in-form Felix Auger Aliassime stands in his way who is looking to claim his third consecutive scalp.
Novak Djokovic leads Taylor Fritz 10-0 across their career - this might be the best opportunity the American has had at his home major. Can he cause the upset?
2025 Wimbledon Champion Iga Swiatek is one of the favourites to win this US Open title, but she could have her hands full against the in-form Ekaterina Alexandrova.
Taylor Fritz is the last American hope standing in the men's draw, but could he be in trouble when he faces an unheralded Czech?
Andrey Rublev has performed well at majors across his career, but could he be challenged by a qualifier that has reached the third round in his first major?
It's been four years since Emma Raducanu made a fairytale run winning the US Open as a qualifier - can she get past a top-10 player to advance at Flushing Meadows?
Some big names could be in trouble against some tricky second-round opponents, while an unheralded Australian should be on his way to the third-round.
We enter the second-round of the US Open, and is there a top-10 seed in danger against an in-form countrywoman?