All eyes will be on Tom Trbojevic and his likelihood to play with the star fullback key to betting in Manly's clash at Brookvale with the Raiders.
One of the biggest rivalries in Rugby League sees its next chapter play out and unlike much of the last decade, it will be the Bulldogs who are heavily favoured.
Gold Coast cost themselves their season with a poor start in 2024 and history seems to be repeating in 2025, landing the Knights in a good spot to start 3-0.
The Dolphins have been terribly disappointing through two weeks and now face a critical home game against the ascendant Tigers that they absolutely must win.
Cronulla have been around the top of the ladder every year under Craig Fitzgibbon and show no signs of regression under, making for tough sledding even for a resilient South Sydney outfit.
The fiery Queensland derby has lost some panache in recent years as both clubs have struggled for relevance but with expectations high in Brisbane and desperation rife in Townsville, this shapes as a big match.
With both teams coming off big underdog wins, the Warriors and the Roosters will be hoping to ride that high to another victory.
Round 3 kicks off with the Grand Final rematch between Melbourne and Penrith with the Storm fresh off a bye and the Panthers off being the shortest beaten favourite in two decades.
Melbourne are missing their star halves pairing but even still look wonderful value against a plodding Newcastle team that is showing its true colours this year.
Tom Trbojevic has managed to stay healthy through two weeks and that looks the difference when the Sea Eagles tackle old rivals Parramatta on Sunday afternoon.