Canterbury return to their spiritual home of Belmore on Sunday night but they will not get an easy run of it against a Titans team playing their first match of the season.
Parramatta were humiliated in Round 1 against Melbourne but that puts them in good shape to get the job done against the Wests Tigers.
Cronulla have long had the wood on North Queensland but in the throes of an arduous period of travel, the Sharks look vulnerable to a team that is in a prime bounceback spot.
St George Illawarra failed to collect the two points in their opening round clash with Canterbury but will be much more confident against a banged-up South Sydney.
The biggest mismatch of the round - and the biggest mismatch of the opening two rounds in at least 17 seasons - sees the four-time defending premiers Penrith expected to annihilate the Sydney Roosters.
The Warriors are the only team to be beaten as a favourite in Round 1 and start as a home underdog in Round 2, having them primed for a bounceback against Manly.
Round 2 kicks off with a match that will likely have finals ramifications down the road with fringe eight teams Newcastle and the Dolphins squaring off in the Hunter.
The Dolphins will be keen to put Round 1 behind them while the Dragons put a line in the sand with a super-impressive performance and will be hoping to build on an impressive victory.
One of the best matches of Round 2, Las Vegas winners Manly and the Sydney Roosters square off at Brookvale with both teams starting the season in red-hot form.
Melbourne have dominated New Zealand in recent years and can continue that superiority at home with the Warriors missing their all-important fullback.