The Saints and Bears both sit last in their division and are in desperate need of a win when the two meet in Chicago.
Tennessee moved on from Brian Callahan earlier in the week and it gives the Titans some chance against New England and their former head coach Mike Vrabel.
Miami seem on the precipice of firing coach Mike McDaniel but the innovative mentor may get a reprieve when the Dolphins head to Cleveland to meet the Browns.
Kansas City remain the team to beat in the AFC West but once more they are being severely overrated by the market.
Carolina have gotten their season going with some heart-attack wins while the New York Jets are chasing their first victory under new coach Aaron Glenn.
The Super Bowl winning champion Eagles have found themselves in a rut and travelling to Minnesota is no way to cure one's ills.
Favourites have a great record in international matches and the Rams should continue that when they meet the Jags in London.
Joe Flacco is now at the Bengals to cover for the injured Joe Burrow and he gives Cincinnati a fighting chance against division rivals Pittsburgh.
The Bears went into their bye off back to back wins and will be looking to continue their momentum when they travel to Washington.
Fresh off their first loss of the season, the Buffalo Bills will be looking to get back on track when they head to Atlanta to play the Falcons.