The Bears travel to Levi's Stadium for a game that will have critical implications for playoff seeding within the NFC.
The best game of Week 17 takes place in the late Sunday window as the playoff bound Eagles and Bills square off in Buffalo.
It's the Tank Bowl - with the loser of this game likely to walk away with the number one overall pick in the 2026 NFL Draft.
Atlanta go in to Week 17 as big home underdogs but the number does not look big enough against a Rams team that thrives this time of year.
Jordan Love and Lamar Jackson are both on the sidelines, so it's the battle of the backups when the Ravens and Packers meet.
Two of the hottest teams in football meet when the Houston Texans travel to play the Los Angeles Chargers.
The Saints are starting to build something under the stewardship of Kellen Moore and look like a strong bet to best the down-and-out Titans.
The season is long gone for the Cleveland Browns but they will relish playing the role of spoiler against hated rivals Pittsburgh.
Carolina have defied expectations all season and can do so again when hosting Seattle in a must-win game for both organisations.
The Patriots have a tremendous recent record against the Jets but New York look like a great bet as a big home underdog.