NFL Tips – San Francisco 49ers @ Arizona Cardinals – Week 11 2022

Betseeker’s expert NFL tipsters have you covered for the best tips and predictions for every game of the NFL season.

The NFL heads to Mexico City for a Monday Night Football clash featuring two teams from the NFC West.

Best Bet


Colt McCoy has been a solid backup option for the Cardinals and bettors should have plenty of faith in taking the Cards with the points here.

In four games as starter in place of Kyler Murray, McCoy has a 3-1 record including a 27-17 win over the Los Angeles Rams last week.

While McCoy doesn’t make the spectacular plays that Murray is capable of, he is more consistent down to down and brings a higher floor to the Cards offence.

Last season he even led Arizona to a 31-17 win over their division rivals at Levi’s Stadium, when the 49ers started 3.5 point favourites.

Yes, there are major differences between the teams from last year to this year – the Cards defence is not playing well – but eight points in a divisional game is too much when neither team has been strong against the number.

Same Game Multi

Cardinals +8, DeAndre Hopkins TD, Christian McCaffrey TD

Hopkins has two touchdowns in four games since returning from suspension and with his incredible catch radius, he is always a threat to score. McCaffrey has three touchdowns in as many games since joining the Niners and is a threat as both a runner and receiver.

Value Bet

Trey McBride
To Score A Touchdown

McBride has mostly been the bridesmaid this season but with Cardinals TE1 Zach Ertz missing with injury, the Colorado State product should get more receiving opportunities.

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Tim is a wagering industry veteran, having spent more than a decade at Sportsbet, BetEasy, TAB and William Hill working in trading and content.