NFL Tips – Rams @ 49ers – Week 10 2025

Both teams come into this battle locked on six wins so this will be a pivotal contest when it comes to deciding the NFC West.

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Best Bet

49ers +5.5
Line
Bet Now
$1.88

Kyle Shanahan’s record against his old protege Sean McVay is becoming too much to ignore in this battle.

The 49ers upset the Rams earlier this season as 8.5 point underdogs, moving Shanahan to an 11-7 record all time in their coaching battle, both head to head and against the line.

The numbers really are damning. McVay is just 1-3 against the line as road favourite against Shanahan, and remarkably, the Rams have lost – straight up – seven of their last eight when favoured against the Niners.

On the field, the Niners have started to find their groove in the run game since the return of George Kittle. While he hasn’t posted big numbers in the passing game, they sure look better running the football with the all pro in the lineup.

Getting the big start at home, San Francisco is the play here.


Same Game Multi

49ers +5.5, McCaffrey Over 65.5 Rushing Yards & TD, Kittle 4+ Catches
Same Game Multi
Bet Now
$5.50

The 49ers are playing a lot of dime personnel which should encourage San Francisco to stick to the run, which will mean McCaffrey hitting.

George Kittle has four catches in three of his four games this season.


Value Bet

Christian McCaffrey
2+ Touchdowns
Bet Now
$4.20

Few players have the ability to find the end zone like McCaffrey and San Francisco’s improved ability to run the ball has helped score two in two of his last three games.

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Frankie has spent more than a decade working in the Australian wagering industry and is widely regarded for his expertise in AFL, NRL and horse racing tips.