NFL Tips – Panthers @ 49ers – Week 12 2025

The Panthers will be looking to take the lead in the NFC South, while the 49ers need to win to stay in touch in the NFC West.

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Best Bet

49ers -7.5
Total

Good teams this season have had little trouble with the Panthers and expect the same for the 49ers.

Carolina have benefited from a very soft schedule in the worst division in football to build their 6-5 record. Against teams with winning records, they have a solitary win, in a bizarre game against the Packers.

Against other teams with winning records, they have losses by 16 to Jacksonville, 29 to New England, and 31 to Buffalo.

Christian McCaffrey gets his first game against his old team and with Carolina struck by injuries at the linebacker position, quarterback Brock Purdy should be able to feast over the middle passing to McCaffrey and star tight end George Kittle.

Bryce Young is coming off the best game of his career last week but it is only the second time the have put up more than 200 yards passing this season.

Regression is a cruel mistress and it is coming for the Panthers.


Same Game Multi

49ers -7.5, Kittle Over 55.5, McCaffrey Over 45.5 Receiving Yards & TD
Same Game Multi

Given the injuries on the Panthers and Brock Purdy’s ability to connect over the middle of the field, Kittle and McCaffrey should both be in for big days.


Value Bet

Christian McCaffrey
First Touchdown

Given this is the McCaffrey revenge game, take him for everything when it comes to scoring. First, 2+, and 3+ scores all look highly achievable.

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Frankie has spent more than a decade working in the Australian wagering industry and is widely regarded for his expertise in AFL, NRL and horse racing tips.