NFL Tips – Jaguars @ 49ers – Week 4 2025

The unbeaten 49ers have been handed their share of injury worries but it has not stopped them marching to a 3-0 start to the season.

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Best Bet

49ers -3.5
Line

The 49ers have just gone about their business but their ability to get the job done in the face of adversity is incredibly admirable. A talent-deficient offense that loses Purdy and Kittle should be there to be beat but Mac Jones led the Niners to two straight wins. Purdy returns this week and should lead his team to a win against a team that is going through some growing pains under new head coach Liam Coen.

The Jags are 2-1 but their loss against the Bengals still surely stings.

San Francisco are 11-4 ATS off playing Arizona while they are 29-16-1 ATS under Kyle Shanahan off playing the NFC West.

The Jags have covered just three of 15 on the West Coast.

The Niners are a nice bet.


Same Game Multi

Travis Etienne TD/Ricky Pearsall TD/Brock Purdy Over 10.5 Rush Yards
Same Game Multi

Travis Ettienne has maintained the RB1 ticket at the Jags even with Bhayshul Tuten. He has scored in his last two.

Ricky Pearsall has played at last 84% of snaps in every game with nine more targets than any other wide out or tight end.

Brock Purdy has at least 12 rushing yards in his last three.


Value Bet

Jake Tonges
To Score A Touchdown

The unfashionable Jake Tonges has established a role in the 49ers offense, one that has increased with George Kittle sidelined. Tonges has nine catches in three weeks including a single touchdown. That TD came with Brock Purdy at quarterback and he returns this week. Tonges is a nice bet.

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Frankie has spent more than a decade working in the Australian wagering industry and is widely regarded for his expertise in AFL, NRL and horse racing tips.