NFL Tips – Cardinals @ Colts – Week 6 2025

The Cardinals are steel reeling from their humiliating implosion against the Titans last week but that puts them in a good spot against an overrated Colts outfit.

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Best Bet

Cardinals +7.5
Line

We are not at a point where we can even consider Indianapolis laying over a touchdown so the only way to look at this game is betting the plus.

The Cardinals had the Titans on toast last week before a hysterical implosion that included a butchered touchdown and an intercept-turned-into-a-fumble-recovery-touchdown.

This is a good spot to be with Arizona. Kyler Murray is 33-18-2 ATS as an underdog while teams off facing the Titans are 33-20-2 ATS the week after.

Happy to take on the Colts too with teams off a win of 30-plus in Week 1- covering at just 39%.

Negative regression is coming to the Colts. The plus is way too big here.


Same Game Multi

Michael Carter TD/Michael Carter Over 14.5 Rec Yards/Jonathan Taylor Over 17.5 Rec Yards
Same Game Multi

Michael Carter has taken over RB1 duties and don’t expect Emari Demercardo to be encroaching on his workload after last week’s embarrassment. He scored in his first start in the role this season last week and had five catches for 22 yards.

Jonathan Taylor has at least 16 receiving yards in every game this year.


Value Bet

Kyler Murray
To Score A Touchdown

Kyler Murray was hardly the biggest villain for the Cardinals last week after Emari Demercado ran 71 yard only to throw a touchdown away through hubris while Darion Taylor-Demerson pulled off a key interception only to fumble it in a play that directly led to a Titans touchdown. He will feel some responsbility for the loss and he rushed for his first touchdown of the season last week. Averaging five carries a game he looks a nice price to score.

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Nick has spent more than 15 years working in wagering around the world and is a regular NRL columnist for The Guardian.