NFL Tips – Cardinals @ 49ers – Week 3 2025

betseeker nfl week 3 tips

Arizona will be looking to preserve their unbeaten record when they head to California to play San Francisco.

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Best Bet

49ers -2.5
Line

Whether Brock Purdy plays or not – he shapes as a game time decision, with Mac Jones the alternate – the 49ers look a strong bet at home.

Admittedly the 49ers record at home last two seasons has been awful against the number – 4-12 – but seldom have they been laying less than a field goal.

There are definite parallels between these teams. Both are unbeaten. Both have been the Saints in New Orleans. Both wins have been by one score.

But the Cardinals made hard work of the Panthers, allowing a backdoor cover at home, while the 49ers Week 1 victory over the Seahawks looks better given that team’s Week 2 effort.

The 49ers defence has been particularly strong, ranking in the top ten in just about every metric, and they have been excellent on third down offensively, ranking second in the league.

They can take advantage of a Cardinals defence that has been giving up the second most first downs in the league. 49ers coach Kyle Shanahan is the master of taking what the defence gives.

The home team are the play here.


Same Game Multi

49ers -2.5, McCaffrey 50+ Receiving & 60+ Rushing Yards
Same Game Multi

McCaffrey missed both games against the Cards last year but if you turn back a year, he absolutely torched them, putting up 150 yards in both. Shanahan has made ample use of his queen on the chess board – he leads the NFL in touches through two weeks.


Value Bet

Jake Tonges
To Score A Touchdown

With George Kittle out, the tight end snaps are going to Tonges and Luke Farrell, but the former Bear has received twice as many targets. With a score in Week 1 already, he is a huge price to go in again.

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Frankie has spent more than a decade working in the Australian wagering industry and is widely regarded for his expertise in AFL, NRL and horse racing tips.