NFL Tips – 49ers @ Saints – Week 2 2025

betseeker nfl week 2 predictions

Key injuries to the 49ers led by QB Brock Purdy makes the struggling Saints a nice bet as a home underdog in Week 2.

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Best Bet

Saints +3.5
Line

The story out of this one is the heavy injury toll that has hit the already depleted 49ers. Star tight end George Kittle left last week’s win over the Seahawks early while QB Brock Purdy was ruled out midweek with a variation of turf toe. Mac Jones will make his first start as a 49er. Jones is 4-14 the last two seasons with the Pats an Jags.

Expectations for the Saints are extremely low this year with new coach Kellen Moore needing to rebuild even if he does not realise it. They are a decent show this week though against the banged-up Niners.

Home underdogs against unbeaten teams cover at 63% while underdogs in games with a total less than 42 cover at north of 60%.

In a grind the points are the play.


Same Game Multi

Juwan Johnson 6+ Receptions/Christian McCaffrey Over 83.5 Rush Yards
Same Game Multi

Juwan Johnson is a beast who pulled in eight catches on 11 targets in Week 1, making it three straight games with at least six catches.

With Purdy and Kittle out, the 49ers will lean on the run more than they usually do. That bodes well for Christian McCaffrey, who ran for 69 yards in the opener and has made a career out of high volume, high return games.


Value Bet

Juwan Johnson
Anytime Touchdown

Veteran Saints Tight End Juwan Johnson played 99% of snaps and had 11 targets in Week 1 and is clearly a favourite of QB Spencer Rattler. He only posted three touchdowns last year but has at least six catches in three straight games and is due positive touchdown regression.

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Frankie has spent more than a decade working in the Australian wagering industry and is widely regarded for his expertise in AFL, NRL and horse racing tips.