NFL Tips – 49ers @ Colts – Week 16 2025

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Best Bet

Under 46.5

Total Points

$1.90

With both teams likely to lean heavily on the run game the under looks a highly attractive bet in this one.

Philip Rivers can barely throw the ball which means a lot of quick and short completions, and the Colts still ran Jonathan Taylor 25 times last week despite him averaging well under three yards per carry. This will help keep the clock rolling.

The Colts longest offensive play last week was 17 yards and it’s hard to see them generating many explosive plays in this one either.

Meanwhile, the 49ers rank seventh for rushing attempts despite being 31st for yards per carry. The Colts defence is still playing hard, keeping the Seahawks to 18 points last week.

Everything points to a low scoring grind here.

Same Game Multi

Under 46.5, Taylor Over 23.5 Rush Attempts, McCaffrey Over 18.5 Rush Attempts

Same Game Multi

$6.50

Expecting a run heavy gameplan, especially from the Colts, and McCaffrey has cleared this number in his last three games.

Value Bet

Christian McCaffrey

First Touchdown

$5.00

McCaffrey has 12 scores in his last 10 games and the 49ers certainly seem like the team more likely to open the scoring, especially with Kyle Shanahan’s ability to script a gameplan.

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